Metabolic effects of a PPaRa agonist duRing fasciolosis tReatMent in sheeP

The liver fluke, Fasciola hepatica (F. hepatica), is a common parasite of ruminants in many countries in the temperate climates and often causes important production losses in infected animals [1, 9, 11, 14, 29, 39]. Natural fasciolosis in sheep develops clinical manifestations of acute, subacute and chronic infection according to numbers of metacercaria ingested in a period of time [1, 4, 11, 14, 39]. Similarly, the pathogenecity and clinical aspect of fasciolosis are also associated with the number of flukes [1, 4, 11, 24, 39, 40]. The disease occurs in two phases: the parenchymal phase during migration of flukes through the liver parenchyma in which they cause traumatic damage to the parenchyma in the form of necrosis, fibrosis and cirrhosis, and the biliary phase which coincides with their residence in the bile ducts and is characterized by hyperplasia of the bile duct epithelium that eventually leads to cholangitis and biliary obstruction [1, 4, SUMMARY